6,501 research outputs found

    How Learning and Living Resilience amidst Experiences of Difference, Stigma, Marginalization, and Loss Contributed to my Identity as a Social Justice Educator: A Scholar Personal Narrative

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    This qualitative study, written as a Scholarly Personal Narrative (SPN), explores how experiences of difference, stigma, marginalization, and loss resulted in an evolving social justice identity further shaped by resilience and hegemony. Living in a family defined by mental illness and poverty, the narrative arc of the SPN explores how this scholar learned and lived resilience, ultimately resulting in a passion for social justice. The discovery of hegemonic norms at play ultimately opened new understandings, which evoked healing, joy, and a desire to build classrooms where students can claim the power of their own stories. This study recommends the need to extend social justice beyond the walls of academia as a way to cultivate environments that honor the lived experiences of all people while also challenging hegemonic norms that oppress and marginalize. It further recommends using other theoretical lenses beyond the risk resilience binary as a way to disrupt the overcoming narrative while challenging deficit thinking so prevalent in how we frame our lives and make meaning of our experiences

    Probing the parton densities of virtual photons with the reaction gamma^*gamma->jets at LEP

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    We present a next-to-leading order calculation of jet production in gamma^*gamma collisions from e+e- scattering in a region where the virtuality Q^2 of the probing virtual photon is small compared to the transverse jet energy. The calculation is based on the phase-space slicing method. The initial state singularity of the virtual photon is factorized into the structure function of the virtual photon, using the MS-bar factorization scheme for virtual photons. Numerical results are presented for LEP2 conditions. The perturbative stability of the pure direct virtual photon approach is compared to that of including resolved virtual photons in different regions of Q^2. We make predictions for cross sections which suggest that different parametrizations of virtual photon parton densities should be distinguishable by measurements of jet cross sections at LEP.Comment: 19 pages, 8 eps figue

    My colleagues (do not) think the same: Middle managers’ shared and separate realities in strategy implementation

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    How does middle managers’ sensemaking of other middle managers’ attitudes to a new strategy affect strategy implementation? We explore this question using a qualitative-abductive approach. Our investigation of the implementation of a top-down strategy in the plant of a multinational German engineering company revealed that middle managers experiencing ambiguity make sense of other middle managers’ attitudes to the strategy in social interactions. Based on their understanding of their colleagues’ attitudes, middle managers construct shared and separate realities about the strategy to be implemented. While shared realities are subjectively experienced commonalities, separate realities are subjectively experienced differences from others’ attitudes to the strategy. In our case, middle managers’ shared realities were associated with inaction on strategy implementation, whereas middle managers’ separate realities were related to initial actions to implement the strategy. Our findings suggest that middle managers’ sensemaking of other middle managers’ attitudes to a new strategy can shape their strategy implementation behavior

    Forward Jet Production at small x in Next-to-Leading Order QCD

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    The production of forward jets of transverse energy E_T\simeq Q and large momentum fraction x_jet >> x is calculated in next-to-leading order including consistently direct and resolved virtual photon contributions. The predictions are compared to recent ZEUS and H1 data. Good agreement with the data is found.Comment: 11 pages, 3 eps figues; text in 2.1 clearified, figure 2 slightly changed; version to appear in Phys. Lett.

    Pesquisa sobre os recursos hídricos em microbacias rurais do bioma Mata Atlântica - Rio de Janeiro.

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    A partir do ano 2003, alguns projetos foram submetidos e aprovados na Embrapa Solos (CNPS) com enfoque nos recursos hídricos, no âmbito de bacias hidrográficas do bioma Mata Atlântica, mais especificamente no Estado do Rio de Janeiro. Estes projetos foram executados não somente pelos profissionais de recursos hídricos, mas de forma interdisciplinar e interinstitucional, com envolvimento de diversas unidades da Embrapa, universidades, ONGs e outras instituições do Estado do Rio de Janeiro, bem como com atuação nacional e internacional. Desta forma, algumas microbacias foram instrumentalizadas e monitoradas nos últimos anos sob o aspecto de qualidade da água, vazão e precipitação, infiltração e escoamento superficial (balanço hídrico), dentre outros, permitindo entender a relação da pressão antrópica, principalmente da agricultura e a disponibilidade dos recursos hídricos. Neste período muitos alunos desenvolveram suas teses, dissertações e monografias, gerando uma série de publicações que se encontram disponíveis, tanto no site da Embrapa Solos como citadas no Currículo Lattes dos pesquisadores envolvidos. Mais recentemente, tem-se buscado também dar maior ênfase à questão dos serviços ambientais hídricos, contemplados em projetos em desenvolvimento. Portanto, este trabalho tem o propósito de apresentar as principais linhas de pesquisa em recursos hídricos, desenvolvidas por pesquisadores da Embrapa Solos no bioma Mata Atlântica - Rio de Janeiro, assim como as principais áreas de estudo, projetos, parcerias relacionadas, perspectivas e desafios

    Maker Movements, Do-It-Yourself Cultures and Participatory Design: Implications for HCI Research

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    Falling costs and the wider availability of computational components, platforms and ecosystems have enabled the expansion of maker movements and DIY cultures. This can be considered as a form of democratization of technology systems design, in alignment with the aims of Participatory Design approaches. However, this landscape is constantly evolving, and long-term implications for the HCI community are far from clear. The organizers of this one-day workshop invite participants to present their case studies, experiences and perspectives on the topic with the goal of increasing understanding within this area of research. The outcomes of the workshop will include the articulation of future research directions with the purpose of informing a research agenda, as well as the establishment of new collaborations and networks

    Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges

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    Linker histone H1 (H1) is an abundant chromatin-binding protein that acts as an epigenetic regulator binding to nucleosomes and altering chromatin structures and dynamics. Nonetheless, the mechanistic details of its function remain poorly understood. Recent work suggest that the number and position of charged side chains on the globular domain (GD) of H1 influence chromatin structure and hence gene repression. Here, we solved the solution structure of the unbound GD of human H1.0, revealing that the structure is almost completely unperturbed by complex formation, except for a loop connecting two antiparallel β-strands. We further quantified the role of the many positive charges of the GD for its structure and conformational stability through the analysis of 11 charge variants. We find that modulating the number of charges has little effect on the structure, but the stability is affected, resulting in a difference in melting temperature of 26 K between GD of net charge +5 versus +13. This result suggests that the large number of positive charges on H1-GDs have evolved for function rather than structure and high stability. The stabilization of the GD upon binding to DNA can thus be expected to have a pronounced electrostatic component, a contribution that is amenable to modulation by posttranslational modifications, especially acetylation and phosphorylation. Keywords: CD; NMR; histone; nucleosome; protein electrostatics; protein stability; protein structur

    Disordered RNA chaperones can enhance nucleic acid folding via local charge screening

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    This work is licensed under a Creative Commons Attribution 4.0 International License.RNA chaperones are proteins that aid in the folding of nucleic acids, but remarkably, many of these proteins are intrinsically disordered. How can these proteins function without a well-defined three-dimensional structure? Here, we address this question by studying the hepatitis C virus core protein, a chaperone that promotes viral genome dimerization. Using single-molecule fluorescence spectroscopy, we find that this positively charged disordered protein facilitates the formation of compact nucleic acid conformations by acting as a flexible macromolecular counterion that locally screens repulsive electrostatic interactions with an efficiency equivalent to molar salt concentrations. The resulting compaction can bias unfolded nucleic acids towards folding, resulting in faster folding kinetics. This potentially widespread mechanism is supported by molecular simulations that rationalize the experimental findings by describing the chaperone as an unstructured polyelectrolyte.Swiss National Science FoundationEuropean Molecular Biology OrganizationIntramural Research Program of the NIDDK at the National Institutes of Healt
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